![]() ![]() In mice, and perhaps in humans, this effect is mediated by the skin. ![]() Prolonged exposure to reduced oxygen levels (e.g., living at high altitude) leads to increased synthesis of EPO. Perhaps an EPO-induced increase in their hematocrit - leading to a reduction in heart rate - is responsible. This difference can be detected by a test of the athlete's urine.Īnother problem: since recombinant EPO became available, over two dozen young competitive cyclists have died unexpectedly (usually during the night). Although recombinant EPO has exactly the same sequence of amino acids as the natural hormone, the sugars attached by the cells used in the pharmaceutical industry differ from those attached by the cells of the human kidney. Some cyclists (and distance runners) have used recombinant EPO to enhance their performance. Severe blood loss in Jehovah's Witnesses, whose religion forbids them to receive blood transfusions, can also be helped with recombinant EPO.īecause EPO increases the hematocrit, it enables more oxygen to flow to the skeletal muscles. ![]()
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